Prague is an endurance-testing 14:50 hrs from Brussels by Flixbus, so why not break up your journey by stopping at some fab places en-route like Dresden which is only 1 hour 49 mins from Prague by coach and before that, Leipzig, and Kassel?
It’s also worth remembering that while coaches may (usually) be slower than trains but they have some advantages…
they are (usually) cheaper
they go over hills, sometimes taking you through beautiful scenery (my favourite route in to Spain is by coach)
there are more roads than rails so you can reach the parts that trains can’t reach
they can be incredibly flexible - railway infrastructure is complex…
Planning your own trip to Czechia
Baffled by the number of options for travelling to ?
Why not plan your own trip to one hop at a time by picking and working your way backwards with Trip_Hop?